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1

Antisense therapeutics: is it as simple as complementary base recognition?

Sudhir Agrawal, Ekambar R Kandimalla

Journal:

Molecular Medicine Today

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

2

Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation

Ekambar R. Kandimalla, Denise R. Shaw, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 376 KB

english, 1998

3

Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice

Daria Trabattoni, Alberto Clivio, Dorothy H. Bray, Lakshmi Bhagat, Silvia Beltrami, Giada Maffeis, Eugenio Cesana, Peter Lowry, Francesca Lissoni, Ekambar R. Kandimalla, Timothy Sullivan, Sudhir Agraw

Journal:

Year:

2006

Language:

english

File:

PDF, 286 KB

english, 2006

4

Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines

Fortunato Ciardiello, Rosa Caputo, Teresa Troiani, Gaetano Borriello, Ekambar R. Kandimalla, Sudhir Agrawal, John Mendelsohn, A. Raffaele Bianco, Giampaolo Tortora

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 210 KB

english, 2001

5

Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range

Ekambar R. Kandimalla, Rajendra K. Pandey, Sudhir Agrawal

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 248 KB

english, 2004

6

Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8

Tao Lan, Lakshmi Bhagat, Daqing Wang, Meiru Dai, Ekambar R. Kandimalla, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 288 KB

english, 2009

7

Accessible 5′-end of CpG-containing Phosphorothioate Oligodeoxynucleotides is essential for immunostimulatory activity

Dong Yu, Qiuyan Zhao, Ekambar R Kandimalla, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

8

Modulation of immunostimulatory activity of CpG oligonucleotides by site-Specific deletion of nucleobases

Dong Yu, Ekambar R Kandimalla, Quiyan Zhao, Yanping Cong, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

9

‘Cyclicons’ as hybridization-based fluorescent primer-probes: synthesis, properties and application in real-time PCR

Ekambar R Kandimalla, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 352 KB

english, 2000

10

Effect of chemical modifications of cytosine and guanine in a cpg-motif of oligonucleotides: structure–immunostimulatory activity relationships

Ekambar R Kandimalla, Dong Yu, Qiuyan Zhao, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 266 KB

english, 2001

11

Pseudo-cyclic oligonucleotides: in vitro and in vivo properties

Zhiwei Jiang, Ekambar R Kandimalla, Qiuyan Zhao, Ling X Shen, Antonella DeLuca, Nicola Normano, Mary Ruskowski, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 449 KB

english, 1999

12

Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways

Sai Latha Shankar, Sridhar Mani, Kathleen Norman O'Guin, Ekambar R. Kandimalla, Sudhir Agrawal, Bridget Shafit-Zagardo

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 704 KB

english, 2001

13

Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages

Dong Yu, Ekambar R Kandimalla, Qiuyan Zhao, Yanping Cong, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

14

Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA

Dong Yu, Ekambar R Kandimalla, Qiuyan Zhao, Lakshmi Bhagat, Yanping Cong, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 293 KB

english, 2003

15

Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H

Ling X Shen, Ekambar R Kandimalla, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 618 KB

english, 1998

16

Stereo-enriched phosphorothioate oligodeoxynucleotides: synthesis, biophysical and biological properties

Dong Yu, Ekambar R. Kandimalla, Allysen Roskey, Qiuyan Zhao, Lihong Chen, Jiangdong Chen, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 1.26 MB

english, 2000

17

Corrigenda: Antisense and siRNA as agonists of Toll-like receptors

Agrawal, Sudhir, Kandimalla, Ekambar R

Journal:

Nature Biotechnology

Year:

2005

Language:

english

File:

PDF, 50 KB

english, 2005

18

Antisense and siRNA as agonists of Toll-like receptors

Agrawal, Sudhir, Kandimalla, Ekambar R

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 247 KB

english, 2004

19

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

McManus, Dan C, Lefebvre, Charles A, Cherton-Horvat, Gabriele, St-Jean, Martine, Kandimalla, Ekambar R, Agrawal, Sudhir, Morris, Stephen J, Durkin, Jon P, LaCasse, Eric C

Journal:

Year:

2004

Language:

english

File:

PDF, 542 KB

english, 2004

20

Modulation of Toll-like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA

SUDHIR AGRAWAL, EKAMBAR R. KANDIMALLA

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 2.92 MB

2003

21

Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640

ERIC C. LACASSE, EKAMBAR R. KANDIMALLA, PETER WINOCOUR, TIM SULLIVAN, SUDHIR AGRAWAL, JOHN W. GILLARD, JON DURKIN

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

22

Impact of Site-Specific Nucleobase Deletions on the Arthritogenicity of DNA

Jan L. Bjersing, Andrej Tarkowski, Ekambar R. Kandimalla, Helen Karlsson, Sudhir Agrawal, L. Vincent Collins

Journal:

Year:

2004

Language:

english

File:

PDF, 338 KB

english, 2004

23

Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists

Ekambar R. Kandimalla, Mary Struthers, Andrew J. Bett, Thomas Wisniewski, Sheri A. Dubey, Weiwen Jiang, Melissa Precopio, Zhenhua Sun, Hao Wang, Tao Lan, Sudhir Agrawal, Danilo R. Casimiro

Journal:

Cellular Immunology

Year:

2011

Language:

english

File:

PDF, 543 KB

english, 2011

24

OR.53. Prevention and Treatment of Ovalbumin-induced Inflammation in Mice with Toll-like Receptor Antagonists

Fugang Zhu, Dong Yu, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

25

Su.42. Oligoribonucleotides Containing Arabinonucleosides Act as Potent Agonists of Toll-like Receptors 7 and 8

Tao Lan, Lakshmi Bhagat, Meiru Dai, Daqing Wang, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2008

Language:

english

File:

PDF, 37 KB

english, 2008

26

Su.50. A Toll-like Receptor Antagonist Prevents Development of IL-23-induced Psoriasis-like Dermal Changes in Mice

Fugang Zhu, Dong Yu, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2008

Language:

english

File:

PDF, 36 KB

english, 2008

27

S.106. Studies of Toll-like Receptors 7 and 9 Antisense in a Preclinical Model of Colitis

Daqing Wang, Dong Yu, Wayne Jiang, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

28

S.108. Modulation of Toll-like Receptor 3 Expression with Antisense

Mallikarjuna Putta, Lakshmi Bhagat, Daqing Wang, Dong Yu, Michael Reardon, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

29

S.105. Modulation of Toll-like Receptors 7 and 9 Expression with Antisense for Potential Applications in Autoimmune and Inflammatory Diseases

Lakshmi Bhagat, Daqing Wang, Mallikarjuna Putta, Dong Yu, Michael Reardon, Ekambar Kandimalla, Sudhir Agrawal

Journal:

Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

30

ChemInform Abstract: Synthesis, Purification, and Characterization of Oligoribonucleotides That Act as Agonists of TLR7 and/or TLR8

Tao Lan, Ekambar R. Kandimalla

Journal:

Year:

2012

File:

PDF, 18 KB

2012

31

Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells

Yan-Ping Cong, Sam S Song, Lakshmi Bhagat, Rajendra K Pandey, Dong Yu, Ekambar R Kandimalla, Sudhir Agrawal

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 259 KB

english, 2003

32

Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8

Tao Lan, Mallikarjuna Reddy Putta, Daqing Wang, Meiru Dai, Dong Yu, Ekambar R. Kandimalla, Sudhir Agrawal

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 752 KB

english, 2009

33

PS1-118 Endogenous production of type I and II interferons drives the bimodal kinetcs of response to CpR-2252, a synthetic agonist of TLR9, in mouse liver

Zuzanna Makowska, Nicola La Monica, Ekambar R. Kandimalla, Markus H. Heim

Journal:

Year:

2011

Language:

english

File:

PDF, 42 KB

english, 2011

34

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

Charles S. Ebert Jr., Austin S. Rose, Mihir R. Patel, Stuart M. Hardy, Ekambar R. Kandimalla, Sudhir Agrawal, Jiri Prazma, Harold C. Pillsbury III

Journal:

International Journal of Pediatric Otorhinolaryngology

Year:

2006

Language:

english

File:

PDF, 389 KB

english, 2006

35

Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice

Fu-Gang Zhu, Ekambar R Kandimalla, Dong Yu, Jimmy X Tang, Sudhir Agrawal

Journal:

International Immunopharmacology

Year:

2004

Language:

english

File:

PDF, 634 KB

english, 2004

36

Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma

Devendra K. Agrawal, Jehad Edwan, Ekambar R. Kandimalla, Dong Yu, Lakshmi Bhagat, Daqing Wang, Sudhir Agrawal

Journal:

International Immunopharmacology

Year:

2004

Language:

english

File:

PDF, 440 KB

english, 2004

37

Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice

Yukui Li, Ekambar R. Kandimalla, Dong Yu, Sudhir Agrawal

Journal:

International Immunopharmacology

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

38

Immune modulatory oligonucleotides in the prevention and treatment of OVA-induced eustachian tube dysfunction in rats

Deidra A. Blanks, Charles S. Ebert Jr, Rose P. Eapen, Carlton Zdanski, Ekambar R. Kandimalla, Sudhir Agrawal, Jiri Prazma

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2007

Language:

english

File:

PDF, 434 KB

english, 2007

39

Immune modulatory oligonucleotides in prevention of nasal allergen–induced Eustachian tube dysfunction in rats

Charles S. Ebert Jr, Austin S. Rose, Deidra A. Blanks, Rose P. Eapen, Ekambar R. Kandimalla, Sudhir Agrawal, Jiri Prazma, Harold C. Pillsbury III

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2007

Language:

english

File:

PDF, 269 KB

english, 2007

40

Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity

Daqing Wang, Ekambar R. Kandimalla, Dong Yu, Jimmy X. Tang, Sudhir Agrawal

Journal:

Year:

2005

Language:

english

File:

PDF, 293 KB

english, 2005

41

A TLR9 agonist enhances therapeutic effects of telomerase genetic vaccine

Antonella Conforti, Barbara Cipriani, Daniela Peruzzi, Sridhar Dharmapuri, Ekambar R. Kandimalla, Sudhir Agrawal, Federica Mori, Gennaro Ciliberto, Nicola La Monica, Luigi Aurisicchio

Journal:

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

42

Effect of synthetic agonists of toll-like receptor 9 on canine lymphocyte proliferation and cytokine production in vitro

Michelle Im Hof, Lina Williamson, Artur Summerfield, Vreni Balmer, Virginie Dutoit, Ekambar R. Kandimalla, Dong Yu, Andreas Zurbriggen, Marcus G. Doherr, John Peel, Petra J. Roosje

Journal:

Veterinary Immunology and Immunopathology

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

43

Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties

Dong Yu, Fu-Gang Zhu, Lakshmi Bhagat, Hui Wang, Ekambar R Kandimalla, Ruiwen Zhang, Sudhir Agrawal

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 322 KB

english, 2002

44

CpG penta- and hexadeoxyribonucleotides as potent immunomodulatory agents

Lakshmi Bhagat, Fu-Gang Zhu, Dong Yu, Jimmy Tang, Hui Wang, Ekambar R Kandimalla, Ruiwen Zhang, Sudhir Agrawal

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

45

Secondary structures in CpG oligonucleotides affect immunostimulatory activity

Ekambar R Kandimalla, Lakshmi Bhagat, Yan-Ping Cong, Rajendra K Pandey, Dong Yu, Qiuyan Zhao, Sudhir Agrawal

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

46

Medicinal chemistry and therapeutic potential of CpG DNA

Sudhir Agrawal, Ekambar R Kandimalla

Journal:

Trends in Molecular Medicine

Year:

2002

Language:

english

File:

PDF, 209 KB

english, 2002

47

Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo

Lan, Tao, Wang, Daqing, Bhagat, Lakshmi, Philbin, Victoria J., Yu, Dong, Tang, Jimmy X., Putta, Mallikarjuna R., Sullivan, Tim, La Monica, Nicola, Kandimalla, Ekambar R., Agrawal, Sudhir

Journal:

Organic & Biomolecular Chemistry

Year:

2013

Language:

english

File:

PDF, 588 KB

english, 2013

48

Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice

Zhu, Fu-Gang, Kandimalla, Ekambar R., Yu, Dong, Agrawal, Sudhir

Journal:

Journal of Allergy and Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 1.86 MB

english, 2007

49

Effects of synthetic oligonucleotides on human complement and coagulation∗

Denise R. Shaw, Pradip K. Rustagi, Ekambar R. Kandimalla, Adrienne N. Manning, Zhiwei Jiang, Sudhir Agrawal

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.25 MB

english, 1997

50

[Molecular Biology Intelligence Unit] Toll and Toll-Like Receptors: An Immunologic Perspective || Agonists of Toll-Like Receptor 9

Kandimalla, Ekambar R.

Year:

2005

Language:

english

File:

PDF, 2.05 MB

english, 2005

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